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Learn more about living with lupus and treatment with BENLYSTA

Already taking BENLYSTA?

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real lupus patients taking BENLYSTA (belimumab).

Already Prescribed BENLYSTA?

Whether you've already begun treatment with BENLYSTA or have just received a prescription for it, you are likely to have questions. Most patients do. You'll want to talk to your healthcare provider about how BENLYSTA works and any concerns you might have. In any event, it's helpful to know:

  • BENLYSTA IV was tested in 2,133 lupus patients in the largest successful SLE clinical trial to date.
  • These studies found that adding BENLYSTA to commonly used lupus medications can reduce lupus disease activity. In fact, in clinical trials, BENLYSTA plus other lupus treatments was superior to other lupus treatments alone in reducing lupus disease activity.
  • The reduction in disease activity was mainly due to improvements in the parts of the body most commonly affected among people participating in the trial: the skin, the mouth, the joints and muscles, and the immune system.

The infusion process is one topic that commonly leads to questions for patients. We've answered a few of them here:  Infusion Answers.

Other questions? See our FAQs section for more insights and information.

Learn about financial support programs

Visit BENLYSTA Gateway to get answers about BENLYSTA answered by a live person on our toll-free support line. If you have insurance, but are not able to afford your medication, BENLYSTA Co-pay Program may be able to help.

Continue the commitment

Remember, every patient responds differently to BENLYSTA. You and your doctor can't be certain when or if it will work for you. But you've made the commitment to add BENLYSTA to your treatment plan and that's an important step. Talk with your doctor about all your questions and concerns and continue to receive BENLYSTA as prescribed. If you're prescribed BENLYSTA IV, as you go along you'll become more and more familiar with the infusion process. If you have any issues with it, talk to the infusion staff, your nurse, or your doctor. But do not skip your infusions.

It's important to continue to receive BENLYSTA as prescribed, even if you are feeling better. Talk to your doctor honestly about any positive and negative experiences you have with your treatment.

Working with Your Healthcare Team

Renee, Lacy, and Sheba discuss their relationships with their healthcare teams and the importance of communication.

Watch Now

GSK sponsors ambassadors, who were on BENLYSTA at the time of filming, and pays them for their time and expense in sharing their experiences. Individual results may vary.

Time for your first infusion?

We’re there for you with the First Infusion Guidebook.

Increase the understanding

Help people not living with lupus to understand lupus


BENLYSTA is a prescription medication used to treat adults with active systemic lupus erythematosus (SLE or lupus) who are receiving other lupus medicines.

It is not known if BENLYSTA is safe and effective in people with severe active lupus nephritis or severe active central nervous system lupus, and it has not been studied in combination with other biologics or intravenous cyclophosphamide. Use of BENLYSTA is not recommended in these situations.

Do not receive BENLYSTA if you are allergic to belimumab or to any of the ingredients in BENLYSTA.

Important Safety Information

The most important information to know about BENLYSTA

BENLYSTA can cause serious side effects. Some of these side effects may cause death. It is not known if BENLYSTA causes these serious side effects.

Important Safety Information

The most important information to know about BENLYSTA

BENLYSTA can cause serious side effects. Some of these side effects may cause death. It is not known if BENLYSTA causes these serious side effects.

Tell your healthcare provider right away if you have any of the symptoms listed below while receiving BENLYSTA

  • Infections: fever, chills, pain or burning with urination, urinating often, coughing up mucus, shortness of breath, or diarrhea/vomiting.
  • Heart problems: chest discomfort or pain, shortness of breath, cold sweats, nausea, dizziness, or discomfort in other areas of the upper body.
  • Allergic (hypersensitivity) reactions: itching, swelling of the face, lips, mouth, tongue, or throat, trouble breathing, anxiousness, low blood pressure, dizziness or fainting, headache, nausea, or skin rash. Serious allergic reactions can happen on the day of, or in the days after, receiving BENLYSTA and may cause death.
  • Mental health problems and suicide: thoughts of suicide or dying, attempt to commit suicide, trouble sleeping, new or worse anxiety or depression, acting on dangerous impulses, other unusual changes in your behavior or mood, or thoughts of hurting yourself or others.

Before receiving BENLYSTA also discuss with your healthcare provider if you:

  • think you have an infection or have infections that keep coming back. You should not receive BENLYSTA if you have an infection unless your healthcare provider tells you to.
  • have or have had mental health problems such as depression or thoughts of suicide.
  • have recently received a vaccination or if you think you may need a vaccination. If you are receiving BENLYSTA, you should not receive live vaccines.
  • are taking other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • are allergic to other medicines.
  • are receiving other biologic medicines, monoclonal antibodies, or IV infusions of cyclophosphamide (CYTOXAN®).
  • have or have had any type of cancer.
  • have any other medical conditions.
  • are pregnant or plan to become pregnant. It is not known if BENLYSTA will harm your unborn baby. Females who are able to become pregnant should talk to their healthcare provider about whether or not they will use birth control (contraception) and receive BENLYSTA. If BENLYSTA is recommended, you should use an effective method of birth control while receiving BENLYSTA and for at least 4 months after the final dose of BENLYSTA. Tell your healthcare provider right away if you become pregnant during your treatment with BENLYSTA or if you think you may be pregnant. If you become pregnant while receiving BENLYSTA, talk to your healthcare provider about enrolling in the BENLYSTA Pregnancy Registry. You can enroll in this registry by calling 1-877-681-6296. The purpose of this registry is to monitor the health of you and your baby.
  • are breastfeeding or plan to breastfeed. It is not known if BENLYSTA passes into your breast milk. You and your healthcare provider should talk about whether or not you should receive BENLYSTA and breastfeed.

Possible side effects of BENLYSTA

  • Progressive multifocal leukoencephalopathy (PML). PML is a serious and life-threatening brain infection. PML can result in death or severe disability. Tell your healthcare provider right away if you notice any new or worsening medical problems: memory loss, trouble thinking, dizziness or loss of balance, difficulty talking or walking, or loss of vision.
  • Cancer. Medicines that affect the immune system including BENLYSTA, may increase your risk of certain cancers.

The most common side effects of BENLYSTA are nausea, diarrhea, fever, stuffy or runny nose and sore throat, cough, trouble sleeping, leg or arm pain, depression, headache, and pain, redness, itching, or swelling at the site of injection (when given subcutaneously). These are not all the possible side effects of BENLYSTA. Call your doctor for medical advice about side effects.

Other Important Information

In clinical studies, there have been mixed results regarding how well BENLYSTA works in black/African American patients. Therefore, you should consult with your healthcare provider to determine if BENLYSTA is right for you.

Please see Prescribing Information and Medication Guide for BENLYSTA.

For more information, call the BENLYSTA Gateway at 1-877-4-BENLYSTA (1-877-423-6597)
Monday through Friday, 8 AM to 8 PM Eastern Time.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit, or call 1-800-FDA-1088.