How BENLYSTA Works

Watch this short video to learn more about what lupus is, how it affects the body, and how BENLYSTA can help.

NORMAL B CELL
NORMAL B CELL
This type of white blood cell produces antibodies
ANTIBODY
ANTIBODY
Antibodies attach themselves to germs and try to control or destroy them
GERM
GERM
Viruses, bacteria, and other invaders
BENLYSTA
BENLYSTA
Human monoclonal antibody that binds the B lymphocyte stimulator protein (BLyS)
HEALTHY BODY TISSUE
HEALTHY BODY TISSUE Tissue unaffected by lupus disease activity
AUTOREACTIVE B CELL
AUTOREACTIVE B CELL
These are the "bad" version of B cells that make autoantibodies that may be harmful
AUTOANTIBODY
AUTOANTIBODY
While antibodies protect the body, autoantibodies work against the body
BLyS
BLyS
B Lymphocyte Stimulator (BLyS) is a protein that helps some cells survive including the bad autoreactive B cells
INFLAMED BODY
TISSUE
INFLAMED BODY TISSUE
Part of the body's protection process, also a sign of lupus disease activity

NARRATOR:

BENLYSTA is a prescription medication for adults with active systemic lupus erythematosus who are receiving other lupus medicines. You shouldn’t receive BENLYSTA if you have severe active lupus nephritis or severe active central nervous system lupus, or if you’re taking other biologics or intravenous cyclophosphamide.

Please stay tuned for Safety Information about BENLYSTA. If you have any questions about BENLYSTA, please talk to your doctor, or call 1-877-4-BENLYSTA.

Thank you for watching.

NARRATOR:

The human immune system is made up of organs and lymphatic vessels and nodes.

It also consists of cells and a wide range of chemical messengers and other proteins that are produced by these cells of the immune system.

This is the system that helps protect us from infections caused by bacteria, viruses and other germs.

B cells, a type of white blood cell, are an important component of the immune system.

These cells recognize and fight germs by producing a special type of protein called an antibody.

Antibodies recognize and latch onto germs. This attachment is a key step in how the immune system protects from infection and fights infection.

Working together, the many parts of the immune system play a vital role in maintaining health.

When the immune system is not working properly, however, it can cause illness rather than help maintain health. Systemic lupus erythematosus, or “SLE” is one of many diseases caused by abnormal immune system activity.

In many people with lupus, certain B cells remain in the body longer than they should.

These cells, called autoreactive B cells play a role in causing lupus.

Like other B cells, autoreactive B cells can produce antibodies. But the antibodies released by autoreactive B cells do not fight germs. Instead, these antibodies—which are called “autoantibodies,” attach to normal tissues inside the body.

When this happens, the autoantibodies end up attacking your own body and tissues can become inflamed.

All of the cells of the immune system are influenced by chemical messengers.

For example, one of the chemical messengers that binds to and helps the growth of B cells— including autoreactive B cells—is called “BLyS.” BLyS is short for B Lymphocyte Stimulator.

BENLYSTA works by binding to BLyS.

When BENLYSTA is attached to BLyS, BLyS can no longer bind to and stimulate the autoreactive B cells.

Adding BENLYSTA to your other lupus treatments may help reduce the abnormal immune system activity that contributes to disease activity in lupus.

If you are considering BENLYSTA, ask your doctor about whether this medication may be right for you.

NARRATOR:

And now, Safety Information about BENLYSTA.

BENLYSTA is a prescription medication for adults with active systemic lupus erythematosus who are receiving other lupus medicines.

You shouldn’t receive BENLYSTA if you have severe active lupus nephritis or severe active central nervous system lupus, or if you’re taking other biologics or intravenous cyclophosphamide.

Serious side effects including death have occurred.

Tell your healthcare provider right away if you have any of the following symptoms:

Infections: such as fever, chills, coughing up mucus, pain or burning with urination, urinating often, or warm, red, or painful skin or sores on your body.

Heart problems: such as chest discomfort or pain, or shortness of breath.

Allergic reactions: itching, dizziness or fainting, swelling of the face, lips, mouth, tongue, or throat, headache, trouble breathing, anxiousness, nausea, low blood pressure, or skin rash.

Mental health problems: such as thoughts of suicide or dying, trouble sleeping, new or worse anxiety or depression, acting on dangerous impulses.

Serious allergic reactions can happen on the day of, or in the days after, receiving BENLYSTA and may cause death.

Call your doctor right away if you notice any new or worsening medical problems such as memory loss, trouble thinking, dizziness or loss of balance, difficulty talking or walking, or loss of vision.

BENLYSTA may reduce the activity of your immune system and may increase your risk of certain cancers or brain infection.

Before receiving BENLYSTA, talk to your doctor about your medical conditions, medicines you’re taking, if you’re nursing, pregnant, or may become pregnant, and if you’ve recently received a vaccination or think you may need a vaccination.

Common side effects include nausea, diarrhea, fever, stuffy or runny nose and sore throat, cough, trouble sleeping, leg or arm pain, depression, headache, and pain, redness, itching, or swelling at the site of injection. These are not all the possible side effects of BENLYSTA.