BENLYSTA Injection for Subcutaneous Use


Actual patient
receiving BENLYSTA

For adult patients, BENLYSTA offers two options for subcutaneous injection that you can take in the comfort of your home.

There Are Options Available


BENLYSTA injection for subcutaneous (SC) use comes in two options:


As an autoinjector

Icon: BENLYSTA Prefilled Syringe

As a prefilled syringe


Before you use BENLYSTA SC, your healthcare provider will show you or your caregiver how to give an injection. They will also review the signs and symptoms of possible allergic reactions. Use BENLYSTA exactly as your healthcare provider tells you to. Read the Instructions for Use that come with BENLYSTA to learn the proper way to inject yourself at home.


Both BENLYSTA SC autoinjectors and prefilled syringes are stored in the refrigerator, and the injections are to be taken once a week on the same day. If you forget your injection, don’t worry. There are steps you can take to get back on track. 


Follow the steps to use the autoinjector or prefilled syringe.

Actual patient
receiving BENLYSTA

After you’ve been trained by your healthcare provider, our trained nurses* can talk you through the process over the phone. Call BENLYSTA Cares for over-the-phone support. 

Call BENLYSTA Cares 
Call 1-877-4-BENLYSTA (1-877-423-6597) from 8 AM to 8 PM Eastern Time, Monday through Friday.

*Nurses from BENLYSTA Cares do not give medical advice. They are only able to answer questions about BENLYSTA. These may include help with self-injections, guidance for getting BENLYSTA, answers about the co-pay program, and other general information. They will direct you to your healthcare provider for answers to other types of questions.

If you have questions about your coverage, BENLYSTA Cares is there for you.


Icon: Checklist

Missed Doses 


If you miss your once-weekly scheduled dose of BENLYSTA SC:

  • Take it as soon as you remember.
  • After you've taken your missed dose, inject your next dose at your regularly scheduled time, or continue weekly dosing based on the new day injected.
  • Do not use 2 doses on the same day to make up for a missed dose.
  • Be sure to talk to your doctor or contact BENLYSTA Cares at 1-877-4-BENLYSTA (1-877-423-6597).

In a clinical study in Black patients, a reduction in disease activity was seen but was not statistically significant. Consult your healthcare provider to see if BENLYSTA is right for you.

How Others Have Experienced BENLYSTA


Discover stories of others living with lupus and their experiences with BENLYSTA.



Frequently Asked Questions

  • What is the difference between BENLYSTA for Intravenous Use (IV) and BENLYSTA for Subcutaneous Use (SC)?


    BENLYSTA can be administered in two ways. 


    • IV infusion: It is given to you by a healthcare provider through a needle placed in a vein. This infusion process takes about 1 hour. It is given every 2 weeks for the first three doses and then at 4-week intervals thereafter. This option is available for adults and children (5 years and older).


    • SC injection: BENLYSTA can also be administered through a subcutaneous injection once a week, either with an autoinjector or a prefilled syringe. This option is available for adults only.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • Will my insurance or Medicare cover the cost of BENLYSTA?

    Each insurance policy is different and costs depend on your individual plan. 


    To understand your cost for BENLYSTA, contact your insurance company or call BENLYSTA Cares at 1-877-4-BENLYSTA (1-877-423-6597). BENLYSTA Cares will connect you with BENLYSTA Gateway, who can research your estimated cost for BENLYSTA under your insurance policy.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.
  • What are the most common side effects of BENLYSTA?

    The most common side effects of BENLYSTA are nausea, diarrhea, fever, stuffy or runny nose and sore throat, persistent cough, trouble sleeping, leg or arm pain, depression, headache, pain, redness, itching, or swelling at the site of injection (when given subcutaneously).


    These are not all the possible side effects of BENLYSTA, please look at the Medication Guide for the full list.
    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    Was this helpful?

    Yes, it was helpful.
    No, it was not helpful.

Want to learn more about resources for BENLYSTA?

Whether you are just getting started with BENLYSTA, or have been taking BENLYSTA for a while, BENLYSTA Cares offers support and ongoing resources throughout the course of your treatment.


Looking for BENLYSTA coverage assistance?

With BENLYSTA treatment, you will also have access to assistance in understanding your health insurance coverage with BENLYSTA Gateway & Co-pay Savings Program.