BENLYSTA for Subcutaneous Use (SC) in adults

Self-injecting BENLYSTA

BENLYSTA SC comes in two options for adults only:
  • As an autoinjector
  • As a prefilled syringe

BENLYSTA offers the independence of a weekly self-injection in the comfort of your own home at a time that is convenient for you—after you’ve been trained by a healthcare provider.

To fully understand how to use your medication safely and effectively, talk to your doctor, and watch the entire videos below on the autoinjector and prefilled syringe:


Read the Instructions for Use that comes with BENLYSTA SC.

Before you use BENLYSTA SC, your healthcare provider will show you or your caregiver how to give the injections and review the signs and symptoms of possible allergic reactions.

Use BENLYSTA SC once a week on the same day each week.

Download the Instructions for Use that comes with BENLYSTA SC about the right way to give injections at home and detailed information on prepping, storing and disposing BENLYSTA SC.

Where to Inject

Choose an injection site (abdomen or thigh), as shown in the figure below:

Try to avoid:
  • Injecting into the same site every time
  • Injecting areas where the skin is tender, bruised, red, or hard

BENLYSTA SC should be used only 1 time and then thrown away.

  • Inject within 2 inches of the belly button
  • Inject BENLYSTA SC into a vein (intravenously)
  • Share your BENLYSTA SC with other people. You may give other people a serious infection, or get a serious infection from them
  • Use if dropped onto a hard surface
  • Remove the Needle Cap until right before the injection

Storage and Disposal

Storage Instructions:
  • Store autoinjectors and prefilled syringes in the refrigerator at 36° to 46°F (2° to 8°C).
  • Remove them from the refrigerator and allow them to sit at room temperature for 30 minutes prior to the subcutaneous injection. Do not warm BENLYSTA SC in any other way.
  • Keep BENLYSTA SC in the original package and out of the light.
  • Do NOT freeze BENLYSTA SC.
  • Keep away from heat and sunlight.
  • Safely throw away medicine that is out of date or no longer needed.
  • If you’re planning a short trip, be sure to speak to your doctor and call 1-877-4-BENLYSTA (1-877-423-6597).
Disposal Instructions:

Dispose of the used autoinjector and Ring Cap in a Sharps Container.

  • Ask your healthcare provider for instructions on how to properly dispose of a filled sharps container.
  • Always keep the sharps container out of the reach of children.
  • Do NOT recycle or throw the sharps container in household trash.

Missed Doses

If you miss your once-weekly scheduled dose of BENLYSTA SC:

  • Take it as soon as you remember.
  • After you've taken your missed dose, you can take your next dose on the usual day. Or, if you prefer, you can start a new weekly schedule from the day that the missed dose was administered.
  • For example, if Helen missed her usual dose on Monday and then took it as soon as she remembered on Wednesday, her next weekly dose would be on the following Wednesday.
  • Be sure to talk to your doctor if you have any questions.

Our trained nurses* are available by phone to talk you through your injections.


Plus, ask about how to get ongoing communications, a free travel bag, a sharps disposal container, and more.

*Nurses from BENLYSTA Cares do not give medical advice and will direct you to your healthcare provider for disease-, treatment-, or referral-related questions. Nurses are available by phone Monday - Friday, 8 am - 8 pm, Eastern Time. If calling after hours, please leave a message and a nurse will return your call within 30 minutes.